My research program examines the relationship between core-brain behavior dimensions and psychiatric symptoms of depression, bipolar disorder, and anxiety. Two dimensions that I am particularly focused on pertain to how the brain processes threatening and rewarding events in the environment. My colleagues and I propose that depression, bipolar disorder, and anxiety may be characterized by distinct profiles of reward processing and reward related brain function and that these profiles may reflect bio-signatures of differential risk. I take a multi-modal perspective to my research, incorporating neurophysiology (electroencephalography, event-related potentials) and both structural and functional neuroimaging.